Dr. med. Carolina de Bakker

Fachärztin Gastro­enterologie FMH


Berufliche Erfahrungen

09/17-07/25

Leiterin Gastroenterologie, Ambulante Gastroenterologie Baden, Schweiz

02/16-06/17

Oberärztin (100%), Abteilung Gastroenterologie und Hepatologie, Universitätsspital Basel, Schweiz

07/14-12/16

Assistenzärztin (100%), Abteilung Gastroenterologie und Hepatologie, Universitätsspital Basel, Schweiz

05/14-07/14

Oberärztin Innere Medizin stv (100%), Abteilung Innere Medizin (inkl Notaufnahme), Spitalzentrum Biel, Schweiz

10/12-04/14

Assistenzärztin (100%), Abteilung Allgemeine Innere Medizin, Infektiologie, Notaufnahme, Onkologie
Spitalzentrum Biel, Schweiz

03/11-10/12

Assistenzärztin (100%), Medizinische Klinik III: Klinik für Gastroentorologie und Stoffwechselkrankheiten und Internistische Intensivmedizin, Uniklinikum (RWTH) Aachen, Deutschland

09/06-03/11

PhD Student und Studienärztin (100%), Abteilungen Gastroenterologie und Pathologie,

Universitätsklinikum Maastricht, Maastricht University Medical Center, Holland PhD Projekt: “Colorectal cancer screening”.

06/06-08/06

Assistenzärztin (100%), Abteilung Innere Medizin, Kreiskrankenhaus Bad- Säckingen, Deutschland

11/05-05/06

Assistenzärztin, Abteilung Neurologie (100%), Innere Medizin, Pneumologie und Notaufnahme, Amphia Ziekenhuis Breda, Holland

1998-1999

Wissenschaftliche Mitarbeiterin, Abteilung Kinder- und Jugendpsychiatrie,

Sophia Kinderziekenhuis Rotterdam, Holland-

Ausbildung / Diplome

2016

FMH Gastroenterologie

2016

FMH Allgemeine Innere Medizin

2016

European Board of Gastroenterology and Hepatology Examination (EBGHE)

2015

FMH Prüfung Allgemeine Innere Medizin

2014

PhD Colorectal Cancer Screening, Maastricht University Medical Centre, Holland

2008

GPC (Good Clinical Practice)

2005

Master Medizin, Erasmus Medical Center Rotterdam, Holland

2003

Master Medizin, Erasmus Medical Center Rotterdam, Holland

1997

Gymnasium Breda, Holland

Sonstige berufliche Erfahrungen

10/2010

Presenter: Oral presentation, Dutch Gastroenterology Days, NVGE, Veldhoven, the Netherlands

Abstract: Cardiopulmonary events during colonoscopy screening using conscious sedation

06/2009

Course Faculty member, Presenter in Section on Colorectal cancer screening, ASNEMGE/EAGE, Postgraduate Training Course, Prague/Czech Republic

05/2009

Poster, Digestive Disease Week, Chicago, USA Higher prevalence of CpG island methylator phenotype-positive (CIMP+)

status in advanced adenomas detected using colonoscopy for colorectal cancer (CRC) screening

03/2009

Presenter: Poster presentation section experimental gastroenterology, Dutch Gastroenterology Days, NVGE, Veldhoven, The Netherlands

Abstract: Higher prevalence of CpG island methylator phenotype-positive (CIMP+) status in advanced adenomas detected using colonoscopy for colorectal cancer (CRC) screening

05/2008

Presenter: Poster presentation, Digestive Disease Week, San Diego Abstract: High prevalence of small adenomas in a colorectal cancer screening

population using primary colonoscopy.

03/2008

Presenter: Oral presentation, Dutch Gastroenterology Days, NVGE, 14- Veldhoven, The Netherlands

Abstract: High prevalence of small adenomas in a colorectal cancer screening population using primary colonoscopy.

10/2007

Poster, UEGW, Paris, France Abstract: Primary colonoscopy for colorectal cancer screening in a workplace-based community: compliance and diagnostic yield

10/2007

Presenter: Oral presentation, Dutch Gastroenterology Days, NVGE, Veldhoven, The Netherlands

Abstract: Primary colonoscopy screening for colorectal cancer in a workplace- based community: participation, reasons for (non)participation and acceptance

Sprachen

Holländisch: Muttersprache
Deutsch und Englisch, Französisch,

Mitgliedschaften

FMH
Aargauischer Aerzteverband
Schweizerische Gesellschaft für Gastroenterologie

Wissenschaftliche Publikationen

A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis.

Simons CC, Hughes LA, Smits KM, Khalid-de Bakker CA, de Bruïne AP, Carvalho B, Meijer GA, Schouten LJ, van den Brandt PA, Weijenberg MP, van Engeland M.Ann Oncol. 2013 Aug;24(8):2048-56. doi: 10.1093/annonc/mdt076. Epub 2013 Mar 26.PMID: 23532114 Free article.


Participation in colorectal cancer screening trials after first-time invitation: a systematic review.

Khalid-de Bakker C, Jonkers D, Smits K, Mesters I, Masclee A, Stockbrügger R.Endoscopy. 2011 Dec;43(12):1059-86. doi: 10.1055/s-0031-1291430. Epub 2011 Dec 1.PMID: 22135196 Review.


DNA methylation of phosphatase and actin regulator 3 detects colorectal cancer in stool and complements FIT.

Bosch LJ, Oort FA, Neerincx M, Khalid-de Bakker CA, Terhaar sive Droste JS, Melotte V, Jonkers DM, Masclee AA, Mongera S, Grooteclaes M, Louwagie J, van Criekinge W, Coupé VM, Mulder CJ, van Engeland M, Carvalho B, Meijer GA.Cancer Prev Res

(Phila). 2012 Mar;5(3):464-72. doi: 10.1158/1940-6207.CAPR-11-0315. Epub 2011 Dec 1.PMID: 22135045


The CpG island methylator phenotype in colorectal cancer: progress and problems.

Hughes LA, Khalid-de Bakker CA, Smits KM, van den Brandt PA, Jonkers D, Ahuja N, Herman JG, Weijenberg MP, van Engeland M.Biochim Biophys Acta. 2012 Jan;1825(1):77-85. doi: 10.1016/j.bbcan.2011.10.005. Epub 2011 Oct 28.PMID: 22056543 Review.


Opportunistic screening of hospital staff using primary colonoscopy: participation, discomfort and willingness to repeat the procedure.

Khalid-de Bakker CA, Jonkers DM, Hameeteman W, de Ridder RJ, Masclee AA, Stockbrügger RW.Digestion. 2011;84(4):281-8. doi: 10.1159/000327383. Epub 2011 Oct 26.PMID: 22041853


Test performance of immunologic fecal occult blood testing and sigmoidoscopy compared with primary colonoscopy screening for colorectal advanced adenomas.

Khalid-de Bakker CA, Jonkers DM, Sanduleanu S, de Bruïne AP, Meijer GA, Janssen JB, van Engeland M, Stockbrügger RW, Masclee AA.Cancer Prev Res (Phila). 2011 Oct;4(10):1563-71. doi: 10.1158/1940-6207.CAPR-11-0076. Epub 2011 Jul 12.PMID: 21750209


Cardiopulmonary events during primary colonoscopy screening in an average risk population.

Khalid-de Bakker CA, Jonkers DM, Hameeteman W, de Ridder RJ, Masclee AA, Stockbrügger RW.Neth J Med. 2011 Apr;69(4):186-91.PMID: 21527807 Free article.


N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer.

Melotte V, Lentjes MH, van den Bosch SM, Hellebrekers DM, de Hoon JP, Wouters KA, Daenen KL, Partouns-Hendriks IE, Stessels F, Louwagie J, Smits KM, Weijenberg MP, Sanduleanu S, Khalid-de Bakker CA, Oort FA, Meijer GA, Jonkers DM, Herman JG, de Bruïne AP, van Engeland M.J Natl Cancer Inst. 2009 Jul 1;101(13):916-27. doi: 10.1093/jnci/djp131. Epub 2009 Jun 17.PMID: 19535783


GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer.

Hellebrekers DM, Lentjes MH, van den Bosch SM, Melotte V, Wouters KA, Daenen KL, Smits KM, Akiyama Y, Yuasa Y, Sanduleanu S, Khalid-de Bakker CA, Jonkers D, Weijenberg MP, Louwagie J, van Criekinge W, Carvalho B, Meijer GA, Baylin SB, Herman JG, de Bruïne AP, van Engeland M.Clin Cancer Res. 2009 Jun 15;15(12):3990-7. doi: 10.1158/1078-0432.CCR-09-0055. Epub 2009 Jun 9.PMID: 19509152


Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer.

Glöckner SC, Dhir M, Yi JM, McGarvey KE, Van Neste L, Louwagie J, Chan TA, Kleeberger W, de Bruïne AP, Smits KM, Khalid-de Bakker CA, Jonkers DM, Stockbrügger RW, Meijer GA, Oort FA, Iacobuzio-Donahue C, Bierau K, Herman JG, Baylin SB, Van Engeland M, Schuebel KE, Ahuja N.Cancer Res. 2009 Jun 1;69(11):4691-9. doi: 10.1158/0008-5472.CAN-08-0142. Epub 2009 May 12.PMID: 19435926 Free PMC article.